In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex

Background Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea...

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Bibliographic Details
Published inBMC cancer Vol. 10; pp. 113 - 225
Main Authors Tiscornia, Inés, Bollati-Fogolín, Mariela, Sene, Reginaldo V, Guimarães, Fernando SF, Wanderer, Carla, Trindade, Edvaldo S, Abud, Ana PR, Martins, Sharon T, Buchi, Dorly F, Andrade, Lucas F
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 25.03.2010
Subjects
Calcium carbonate
Cancer
Chemotherapy
Drug therapy
Health aspects
Melanoma
Metastasis
Methods
Uruguay
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Summary:Background Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. Methods Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. Results We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. Conclusion The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies.
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-10-113