Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

• Published in: Diabetes (New York, N.Y.) Vol. 59; no. 12; pp. 3049 - 3057
• Main Authors: FURET, Jean-Pierre, KONG, Ling-Chun, RIZKALLA, Salwa, CLEMENT, Karine, TAP, Julien, POITOU, Christine, BASDEVANT, Arnaud, BOUILLOT, Jean-Luc, MARIAT, Denis, CORTHIER, Gérard, DORE, Joël, HENEGAR, Corneliu
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.12.2010
• Subjects: Adaptation, Physiological; Analysis; Bacteroides; Bacteroides - genetics; Bacteroides - isolation & purification; Bariatric Surgery; Bifidobacterium; Bifidobacterium - genetics; Bifidobacterium - isolation & purification; Biological and medical sciences; Blood Glucose - metabolism; Body composition; Body fat; Calories; Care and treatment; Clostridium - genetics; Clostridium - isolation & purification; Diabetes; Diabetes. Impaired glucose tolerance; DNA Primers; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Escherichia coli; Escherichia coli - isolation & purification; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Faecalibacterium prausnitzii; Feces; Feces - microbiology; Female; Food; Gastrointestinal surgery; Glucose; Humans; Inflammation; Inflammation - etiology; Inflammation - microbiology; Inflammation - physiopathology; Insulin; Lactobacillus; Lactobacillus - isolation & purification; Leptin; Leuconostoc; Leuconostoc - isolation & purification; Life Sciences; Male; Medical sciences; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Obesity; Obesity - microbiology; Obesity Studies; Patient outcomes; Pediococcus; Pediococcus - isolation & purification; Physiological aspects; Polymerase Chain Reaction; Prevotella; Research design; Starvation - microbiology; Surgery; Thinness - microbiology; Weight control; Weight loss; Weight Loss - physiology; France; Endocrinopathy; Human; Digestive system; Surgery; Diabetes mellitus; Gut; Weight loss; Microflora; Inflammation; Adaptation; LEPTIN; GASTRIC BYPASS-SURGERY; ENERGY; PEPTIDE-YY; DIET; MORBIDLY OBESE SUBJECTS; ENDOTOXEMIA; HUMAN COLONIC MICROBIOTA; INSULIN SENSITIVITY; ADIPOSE-TISSUE

Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We an...