MicroRNA roles in the NF-[kappa]B signaling pathway during viral infections

NF-κB signaling network is a crucial component of innate immunity. miRNAs are a subtype of small noncoding RNAs, involved in regulation of gene expression at the posttranscriptional level. Increasing evidence has emerged that miRNAs play an important role in regulation of NF-κB signaling pathway dur...

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Bibliographic Details
Published inBioMed research international Vol. 2014
Main Authors Gao, Zeqian, Dou, Yongxi, Chen, Yixia, Zheng, Yadong
Format Journal Article
LanguageEnglish
Published New York John Wiley & Sons, Inc 01.01.2014
Hindawi Limited
Subjects
Biosynthesis
Cytokines
Gene expression
Genetic aspects
Health aspects
Immune system
Infections
Insects
Kinases
MicroRNA
Proteins
Risk factors
RNA polymerase
Science
Viral infections
Virus diseases
China
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Summary:NF-κB signaling network is a crucial component of innate immunity. miRNAs are a subtype of small noncoding RNAs, involved in regulation of gene expression at the posttranscriptional level. Increasing evidence has emerged that miRNAs play an important role in regulation of NF-κB signaling pathway during viral infections. Both host and viral miRNAs are attributed to modulation of NF-κB activity, thus affecting viral infection and clearance. Understandings of the mechanisms of these miRNAs will open a direction for development of novel antivirus drugs.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/436097