Biochemistry The big catch

The availability of short interfering RNAs (siRNAs) to silence gene expression has revolutionized research in molecular cell biology. But these synthetic siRNAs rely on cellular enzymes for their activity.

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Bibliographic Details
Published inNature (London) Vol. 447; no. 7141; pp. 156 - 157
Main Author Trotta, Christopher R
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 10.05.2007
Subjects
Biochemistry
Cellular biology
Enzymes
Humans
Molecular biology
Nuclear Proteins
Phosphorylation
Phosphotransferases - isolation & purification
Phosphotransferases - metabolism
Ribonucleic acid
RNA
RNA Interference
RNA Splicing
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
RNA, Transfer - genetics
RNA, Transfer - metabolism
RNA-Induced Silencing Complex - metabolism
Transcription Factors - isolation & purification
Transcription Factors - metabolism
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Summary:The availability of short interfering RNAs (siRNAs) to silence gene expression has revolutionized research in molecular cell biology. But these synthetic siRNAs rely on cellular enzymes for their activity.
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ISSN:0028-0836
1476-4687
DOI:10.1038/447156a