Convergence of Wnt, β-Catenin, and Cadherin Pathways

The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, becau...

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Published inScience (American Association for the Advancement of Science) Vol. 303; no. 5663; pp. 1483 - 1487
Main Authors Nelson, W. James, Nusse, Roel
Format Journal Article
LanguageEnglish
Published Washington, DC American Association for the Advancement of Science 05.03.2004
Subjects
Animals
b-catenin
beta Catenin
Biological and medical sciences
Cadherins
Cadherins - metabolism
Catenins
Cell Adhesion
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell Division
Cell Movement
Cell physiology
Cytoskeletal Proteins - metabolism
Fundamental and applied biological sciences. Psychology
Gene expression regulation
Genes
Genetic aspects
Genetic research
Growth Substances - metabolism
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Molecular and cellular biology
Neoplasms - genetics
Neoplasms - physiopathology
Phosphorylation
Physiology
Proteins
Proto-Oncogene Proteins - metabolism
Receptors
Review
Signal Transduction
Somatic cells
Stem cells
Stem Cells - physiology
T lymphocytes
Trans-Activators - metabolism
Transcription, Genetic
Wnt protein
Wnt Proteins
Zebrafish Proteins
United States
Tissue
Signal transduction
Regulation(control)
Review
Cadherin
Cell differentiation
Adhesion
Catenin
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Summary:The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, β-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.1094291