Does man age faster at the everest peak? A hypothesis paper

Oxygen delivery and utilization must be balanced, and maintenance of oxygen homeostasis in arterial blood is mediated by reflexes that are sensitive to oxygen decrease and by release of several factors like Hypoxic Inducible Factor (HIF), which plays a key role in this homeostatic regulation (Semenz...

Full description

Saved in:
Bibliographic Details
Published inJournal of sports science & medicine Vol. 12; no. 1; pp. 205 - 206
Main Author Di Giulio, Camillo
Format Journal Article
LanguageEnglish
Published Turkey Journal of Sports Science and Medicine 01.03.2013
Asist Group
Subjects
Adaptation
Aging
Aging (Biology)
Altitude
Altitudes
Anoxia
Cell cycle
Endocrinology
Free radicals
Gene expression
Health aspects
Homeostasis
Hyperoxia
Hypoxia
Letter to Editor
Life expectancy
Maximum oxygen consumption
Medicine
Metabolism
Mitochondria
Mitochondrial DNA
Neurobiology
Neurosciences
Oxidative stress
Phosphorylation
Physiology
Sea level
Signal transduction
Sleep apnea
Vascular endothelial growth factor
Italy
Online AccessGet full text
ISSN1303-2968
1303-2968

Cover

More Information
Summary:Oxygen delivery and utilization must be balanced, and maintenance of oxygen homeostasis in arterial blood is mediated by reflexes that are sensitive to oxygen decrease and by release of several factors like Hypoxic Inducible Factor (HIF), which plays a key role in this homeostatic regulation (Semenza, 2011). In response to hypoxia, cellular adaptive mechanisms induce expression of HIF, which in turn stimulates Vascular Endothelial Growth Factor (VEGF), important also in pregnancy (Wang et al., 2012), in tumor angiogenesis, during sleep apnea, typical of the elderly and in obese subjects. Considering that life span is correlated with metabolism rate and mitochondria are the site of oxygen consumption (Sohal et al., 2007), the increases in HIF-1α in response to acute and chronic hypoxia have a crucial role in adaptation processes. [...]high altitude results in lower birth rates in all races, considering the reduction in fertility (Verratti, et al., 2008), life on the Everest would theoretically be impossible because of the accelerating ROS production and aging. [...]aging, patients with heart failure or with chronic obstructive pulmonary diseases (COPD) are associated with muscle wasting, in turn correlated to chronic hypoxemia.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-2
content type line 14
ObjectType-Letter to the Editor-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:1303-2968
1303-2968