MODY: History, genetics, pathophysiology, and clinical decision making

Starting with known diabetic patients from the Diabetes Clinic, I recruited their apparently healthy and asymptomatic first-degree relatives (parents, brothers, sisters, and children) for routine oral glucose tolerance tests (OGTTs). The initial objectives were 1 to define the normal range for the O...

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Bibliographic Details
Published inDiabetes care Vol. 34; no. 8; pp. 1878 - 1884
Main Authors FAJANS, Stefan S, BELL, Graeme I
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.08.2011
Subjects
Bell, Graeme I
Biological and medical sciences
Body Weight
Congressional investigations
Decision Making
Diabetes
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic retinopathy
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Health services
Humans
Hyperglycemia
Illinois
Medical genetics
Medical sciences
Metabolic diseases
Michigan
Miscellaneous
Nutrition research
Older people
Physiological aspects
Public health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Reviews/Commentaries/ADA Statements
Studies
Universities and colleges
Young adults
Illinois
Michigan
Endocrinopathy
Human
Maturity onset diabetes young
Nutrition
Pathophysiology
Pathogenesis
Decision making
Genetics
Metabolic diseases
History
Endocrinology
Genetic disease
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Summary:Starting with known diabetic patients from the Diabetes Clinic, I recruited their apparently healthy and asymptomatic first-degree relatives (parents, brothers, sisters, and children) for routine oral glucose tolerance tests (OGTTs). The initial objectives were 1 to define the normal range for the OGTT, 2 to attempt to unmask the potential diabetic subjects who manifest normal glucose tolerance by the standard OGTT and determine whether the diabetogenic activity of cortisone could be used to uncover a subclinical defect in the metabolism of glucose, and 3 to carry out periodic follow-up over many years of the apparently healthy first-degree relatives of diabetic patients.
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ISSN:0149-5992
1935-5548
1935-5548
DOI:10.2337/dc11-0035