Phantom Study on Radiotherapy Planning Using PET/CT -Delineation of GTV by Evaluating SUV

• Published in: JOURNAL OF RADIATION RESEARCH Vol. 51; no. 2; pp. 157 - 164
• Main Authors: Uto, Fumiaki, Shiba, Eiji, Onoue, Seiitchi, Yoshimura, Hitoshi, Takada, Mami, Tsuji, Yoshihiko, Fukugami, Satoshi, Asakawa, Isao, Tamamoto, Tetsuro, Hasegawa, Masatoshi
• Format: Journal Article
• Language: Japanese; English
• Published: England THE JAPAN RADIATION RESEARCH SOCIETY 2010; Oxford University Press
• Subjects: Fluorine Radioisotopes - pharmacokinetics; Fluorodeoxyglucose F18 - pharmacokinetics; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Microspheres; Observer Variation; Phantoms, Imaging; Positron emission tomography; Radiopharmaceuticals - pharmacokinetics; Radiotherapy; Radiotherapy Planning, Computer-Assisted - instrumentation; Radiotherapy Planning, Computer-Assisted - methods; Sport utility vehicles; Tomography, X-Ray Computed
• ISSN: 0449-3060; 1349-9157; 1349-9157
• DOI: 10.1269/jrr.09063

We assessed the usefulness of PET/CT images to determine the target volume in radiotherapy planning by evaluating the standardized uptake value (SUV). We evaluated the imaging conditions and image-reconstruction conditions of PET/CT useful for treatment planning by collecting 18F-FDG images of acrylic spheres (10-48 mm in diameter) in a phantom. The 18F-FDG concentration in the spheres was 10-fold higher than that of the phantom. The contours were delineated according to the SUV by the threshold and regions of interest (ROI) methods. Comparisons of two- and three-dimensional (2D and 3D) acquisition images indicated that the sharpness and quantitative qualities of the sphere boundaries were better in the former than in the latter. In the extraction of outlines using the SUV, outlines obtained at an SUV of 40-50% of the maximum agreed well with the actual acrylic sphere size. 2D acquisition images are more suitable for delineating target volume contours, although 3D acquisition images are more popular in diagnostic imaging. An SUV of 40-50% of the maximum is suggested to be appropriate for GTV contouring of sphere tumors with homogenously distributed 18F-FDG.