LIPO-MICRODIALYSIS : A NEW MICRODIALYSIS METHOD FOR STUDYING THE PHARMACOKINETICS OF LIPOPHILIC SUBSTANCES

A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by MD in vitro. Rec...

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Bibliographic Details
Published inBiological & pharmaceutical bulletin Vol. 21; no. 2; pp. 194 - 196
Main Authors KUROSAKI, Yuji, NAKAMURA, Shinya, SHIOJIRI, Yoko, KAWASAKI, Hiromu
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.02.1998
Maruzen
Subjects
alkylparaben
Analysis
Biological and medical sciences
Chromatography, High Pressure Liquid
General pharmacology
lipid emulsion
lipo-microdialysis
lipophilic substances
Medical sciences
microdialysis
Microdialysis - methods
Parabens - pharmacokinetics
pharmacokinetics
Pharmacology. Drug treatments
Spectrophotometry, Ultraviolet
Benzoic acid derivatives
Ester
Microdialysis
Fat emulsion
Lipophily
Pharmacokinetics
In vitro
Physicochemical properties
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Summary:A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by MD in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7, respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.21.194