Ag2 and Ag3 Clusters: Synthesis, Characterization, and Interaction with DNA

Subnanometric samples, containing exclusively Ag2 and Ag3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we sh...

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Published inAngewandte Chemie (International ed.) Vol. 54; no. 26; pp. 7612 - 7616
Main Authors Buceta, David, Busto, Natalia, Barone, Giampaolo, Leal, José M., Domínguez, Fernando, Giovanetti, Lisandro J., Requejo, Félix G., García, Begoña, López-Quintela, M. Arturo
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 22.06.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
cluster compounds
Deoxyribonucleic acid
DNA
DNA - chemistry
electrochemical synthesis
Electrochemistry - methods
intercalation
Kinetics
silver
Silver - chemistry
cluster compounds
silver
intercalation
electrochemical synthesis
DNA
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Summary:Subnanometric samples, containing exclusively Ag2 and Ag3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag3 clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag3 clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine. Sandwiching silver in DNA: Subnanometric silver clusters (Ag2 and Ag3) were synthesized using a kinetic control procedure. Interaction studies of the clusters with DNA have demonstrated that Ag2 clusters interact only by covalent binding, whereas Ag3 clusters intercalate between the base pairs in DNA (see picture) and induce strong conformational changes.
Bibliography:ark:/67375/WNG-JLV1M6NP-H
Xunta de Galicia - No. POS-A/2013/018
CONICET - No. 01035
This work was supported by Obra Social "la Caixa" (OSLC-2012-007), the European Commission through the FEDER and FP7 programs (0681_InveNNta_1_E; FutureNanoNeeds, FP7-Grant 604602), the MCI Spain (MAT2010-20442 and MAT2011-28673-C02-01), MINECO Spain (MAT2012-36754-C02-01, CTQ2014-58812-C2-2-R), Xunta de Galicia Spain (GRC2013-044, FEDER Funds). D.B. is grateful for the postdoctoral grant from Xunta de Galicia Spain (POS-A/2013/018). F.G.R. and L.J.G. thank the CONICET for grant 01035 and the SXS Beamline (LNLS, Campinas, Brazil) for partial support.
European Commission - No. 0681_InveNNta_1_E; No. 604602
Xunta de Galicia - No. GRC2013-044
istex:F3158DA2E4B2DC6C58EB9A6463095F0BA8B56830
Obra Social - No. OSLC-2012-007
ArticleID:ANIE201502917
MCI - No. MAT2010-20442; No. MAT2011-28673-C02-01
MINECO - No. MAT2012-36754-C02-01; No. CTQ2014-58812-C2-2-R
This work was supported by Obra Social “la Caixa” (OSLC‐2012‐007), the European Commission through the FEDER and FP7 programs (0681_InveNNta_1_E; FutureNanoNeeds, FP7‐Grant 604602), the MCI Spain (MAT2010‐20442 and MAT2011‐28673‐C02‐01), MINECO Spain (MAT2012‐36754‐C02‐01, CTQ2014‐58812‐C2‐2‐R), Xunta de Galicia Spain (GRC2013‐044, FEDER Funds). D.B. is grateful for the postdoctoral grant from Xunta de Galicia Spain (POS‐A/2013/018). F.G.R. and L.J.G. thank the CONICET for grant 01035 and the SXS Beamline (LNLS, Campinas, Brazil) for partial support.
These authors contributed equally to this paper.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201502917