Urinary aHGF, IGFBP3 and OPN as diagnostic and prognostic biomarkers for prostate cancer

• Published in: Biomarkers in medicine Vol. 7; no. 6; pp. 831 - 841
• Main Authors: Prager, Alisa J, Peng, Cynthia R, Lita, Elena, McNally, Debbie, Kaushal, Aradhana, Sproull, Mary, Compton, Kathryn, Dahut, William L, Figg, William D, Citrin, Deborah, Camphausen, Kevin A
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.12.2013
• Subjects: Area Under Curve; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - urine; Biopsy; Cancer therapies; Enzyme-Linked Immunosorbent Assay; Genetic aspects; Glycoproteins; Growth factors; Hepatocyte Growth Factor - urine; Humans; Identification and classification; Insulin-Like Growth Factor Binding Protein 3 - urine; Male; Medical prognosis; Men; Metabolic Networks and Pathways; Neoplasm Staging; Osteopontin - urine; Patients; Prognosis; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Proteins; ROC Curve; Sensitivity and Specificity; Studies
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm.13.112

Serum PSA screening for prostate cancer (PCa) is controversial. Here, we identify three urinary biomarkers - aHGF, IGFBP3 and OPN - for PCa screening and prognostication. Urinary aHGF, OPN and IGFBP3 from healthy men (n = 19) and men with localized (n = 65) and metastatic (n = 36) PCa were quantified via ELISA. Mann-Whitney nonparametric t-test and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) analyses were used to analyze associations. Mean aHGF and IGFBP3 levels were significantly elevated in PCa patients versus controls (p = 0.0006 and p = 0.0012, respectively), and the area under the curve of the receiver operating characteristic curve (indicator of diagnostic accuracy) for aHGF and IGFBP3 was 0.75 and 0.74, respectively. OPN levels were significantly higher in metastatic groups (p = 0.0060) versus localized and controls (area under the curve = 0.68). Urinary aHGF and IGFBP3 exhibit the capacity for diagnostic discrimination for PCa, whereas OPN may indicate presence of metastatic disease.