Nitrogen fixation Endocrine disrupters and flavonoid signalling

Nitrogen fixation is a symbiotic process initiated by chemical signals from legumes that are recognized by soil bacteria. Here we show that some endocrine-disrupting chemicals (EDCs), so called because of their effect on hormone-signalling pathways in animal cells, also interfere with the symbiotic...

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Published inNature (London) Vol. 413; no. 6852; pp. 128 - 129
Main Authors McLachlan, John A, Fox, Jennifer E, Starcevic, Marta, Kow, Kelvin Y, Burow, Matthew E
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 13.09.2001
Subjects
Bacteria
Biology
Endocrine disruptors
Flavonoids
Genes
Hormones
Legumes
Medicago sativa - microbiology
Medicago sativa - physiology
Nitrogen
Nitrogen Fixation
Penis
Pesticides
Pesticides - chemistry
Pesticides - pharmacology
Phenols - chemistry
Phenols - pharmacology
Phytochemicals
Rhizobiaceae - physiology
Signal Transduction - drug effects
Sperm
Symbiosis
Vertebrates
Wildfowl
United States > US
Alaska
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Summary:Nitrogen fixation is a symbiotic process initiated by chemical signals from legumes that are recognized by soil bacteria. Here we show that some endocrine-disrupting chemicals (EDCs), so called because of their effect on hormone-signalling pathways in animal cells, also interfere with the symbiotic signalling that leads to nitrogen fixation. Our results raise the possibility that these phytochemically activated pathways may have features in common with hormonal signalling in vertebrates, thereby extending the biological and ecological impact of EDCs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0028-0836
1476-4687
DOI:10.1038/35093163