Modeling of Myocardium Compressibility and its Impact in Computational Simulations of the Healthy and Infarcted Heart

Simulation of heart function requires many components, including accurate descriptions of regional mechanical behavior of the normal and infarcted myocardium. Myocardial compressibility has been known for at least two decades, however its experimental measurement and incorporation into computational...

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Bibliographic Details
Published inFunctional Imaging and Modelling of the Heart Vol. 10263; pp. 493 - 501
Main Authors Soares, Joao S., Li, David S., Lai, Eric, Gorman III, Joseph H., Gorman, Robert C., Sacks, Michael S.
Format Book Chapter Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.01.2017
SeriesLecture Notes in Computer Science
Subjects
Cardiac simulation
Compressibility
Myocardium
Myocardium
Cardiac simulation
Compressibility
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ISBN3319594478
9783319594477
ISSN0302-9743
1611-3349
DOI10.1007/978-3-319-59448-4_47

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Summary:Simulation of heart function requires many components, including accurate descriptions of regional mechanical behavior of the normal and infarcted myocardium. Myocardial compressibility has been known for at least two decades, however its experimental measurement and incorporation into computational simulations has not yet been widely utilized in contemporary cardiac models. In the present work, based on novel in-vivo ovine experimental data, we developed a specialized compressible model that reproduces the peculiar unimodal compressible behavior of myocardium. Such simulations will be extremely valuable to understand etiology and pathophysiology of myocardium remodeling and its impact on tissue-level properties and organ-level cardiac function.
ISBN:3319594478
9783319594477
ISSN:0302-9743
1611-3349
DOI:10.1007/978-3-319-59448-4_47