Effect of dietary phytoestrogens on human growth regulation: imprinting in health & disease

• Published in: Indian journal of medical research (New Delhi, India : 1994) Vol. 140 Suppl; no. Suppl 7; pp. S82 - 90
• Main Authors: Griffiths, K, Wilson, D W, Singh, R B, De Meester, F
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.11.2014; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Androgens; Chromosomes; Deoxyribonucleic acid; Diabetes; Diet; Diet, Paleolithic; Disease; DNA; DNA methylation; Endocrinology; Epigenesis, Genetic - physiology; Epigenetics; Fatty acids; Female; Flavonoids; Food; Functional foods & nutraceuticals; Gene expression; Genomes; Growth - drug effects; Health aspects; Humans; Influence; Isoflavones; Maternal-Fetal Exchange - drug effects; Maternal-Fetal Exchange - physiology; Phytochemicals; Phytoestrogens - adverse effects; Phytoestrogens - metabolism; Pregnancy; Prostate cancer; Review; Sex Determination Processes - drug effects; Sex Factors
• ISSN: 0971-5916; 0975-9174

This group has advocated a return to the notional Palæolithic diet with fruits, vegetables, roots, leaves, seeds, phytochemical antioxidants and proteins, etc. Phytoestrogens, viz. lignans, isoflavonoids and flavonoids are weak oestrogenic constituents of such a diet and may have a considerable impact on human health and disease. The aim of this paper was to conduct a preliminary overview of about 2000 research-led studies from the 1930s to the present time reported in the literature on flavonoids/isoflavonoids/lignans and to assemble evidence for a future strictly formal literature review on the health benefits and risks of flavonoids in a variety of diseases.