Relationship Between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation

• Published in: Advances in experimental medicine and biology Vol. 1269; p. 87
• Main Authors: Morishita, Shinichiro, Wakasugi, Tatsushi, Kaida, Katsuji, Itani, Yusuke, Ikegame, Kazuhiro, Ogawa, Hiroyasu, Fujimori, Yoshihiro, Domen, Kazuhisa
• Format: Journal Article
• Language: English
• Published: United States 2021
• Subjects: Adrenal Cortex Hormones; Hematopoietic Stem Cell Transplantation; Humans; Male; Muscle Strength; Muscle, Skeletal - metabolism; Oxygen Consumption; Corticosteroid; Muscle oxygen consumption; Rehabilitation; Hematopoietic stem-cell transplantation; Near-infrared spectroscopy
• ISSN: 0065-2598
• DOI: 10.1007/978-3-030-48238-1_14

After hematopoietic stem-cell transplantation (HSCT), patients exhibit decreased muscle strength and muscle oxygen consumption. Furthermore, total corticosteroid dose affects the reduction in muscle strength after HSCT. However, to date, no studies have investigated the relationship between corticosteroid dose and muscle oxygen consumption and saturation in these patients. The purpose of this study was to investigate the relationship between steroid dose and deoxyhemoglobin (ΔHHb) and muscle oxyhemoglobin saturation (ΔSmO ) in patients undergoing HSCT. This study included 17 men with hematologic disease who underwent allogeneic HSCT. We evaluated ankle dorsiflexor muscle force, ΔHHb, and ΔSmO in skeletal muscles by near-infrared spectroscopy (NIRS) in patients before and after HSCT. Peak ankle dorsiflexion, ΔHHb, and ΔSmO decreased significantly after transplantation as compared to measurements taken before transplantation (p < 0.01). The change in peak ankle dorsiflexion from before to after HSCT was not significantly correlated with total steroid dose. However, ΔHHb and ΔSmO from before to after HSCT were significantly correlated with total steroid dose (p < 0.01). This study showed that higher corticosteroid doses are associated with diminished skeletal muscle O consumption and skeletal muscle O demand relative to supply. Therefore, rehabilitation staff, nurses, and physicians should take note of these findings in patients undergoing HSCT. Moreover, physiotherapists should be carefully measuring muscle oxidative metabolism on skeletal muscle when planning physical exercise in such patients.