Childhood Nutrition in Predicting Metabolic Syndrome in Adults: The Cardiovascular Risk in Young Finns Study

• Published in: Diabetes care Vol. 35; no. 9; pp. 1937 - 1943
• Main Authors: JAASKELAINEN, Paula, MAGNUSSEN, Costan G, LAITINEN, Tomi, JOKINEN, Eero, LEHTIMÄKI, Terho, VIIKARI, Jorma S. A, RAITAKARI, Olli T, JUONALA, Markus, PAHKALA, Katja, MIKKILÄ, Vera, KAHONEN, Mika, SABIN, Matthew A, FOGELHOLM, Mikael, HUTRI-KÄHÖNEN, Nina, TAITTONEN, Leena, TELAMA, Risto
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.2012
• Subjects: Adolescent; Adults; Biological and medical sciences; Blood Pressure - physiology; Butter; C-Reactive Protein - metabolism; Cardiovascular diseases; Child; Child, Preschool; Cholesterol; Cohort Studies; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Families & family life; Family medical history; Female; Food; Fruit; Humans; Hypertension; Insulin - blood; Life Style; Lifestyles; Male; Medical research; Medical sciences; Medicine, Experimental; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - epidemiology; Methods; Miscellaneous; Nutritional Status - physiology; Obesity; Original Research; Other metabolic disorders; Physical fitness; Public health. Hygiene; Public health. Hygiene-occupational medicine; Questionnaires; Risk Factors; Triglycerides; Vegetables; Europe; Finland; Endocrinopathy; Human; Nutrition; Metabolic diseases; Cardiovascular disease; Metabolic syndrome; Feeding; Risk factor; Cardiovascular risk; Adult; Predictive factor; Child; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc12-0019

Our aim was to study the associations of childhood lifestyle factors (the frequency of consumption of vegetables, fruit, fish, and meat, butter use on bread, and physical activity) with the metabolic syndrome (MetS) in adulthood. The study cohort consisted of 2,128 individuals, 3-18 years of age at the baseline, with a follow-up time of 27 years. We used the average of lifestyle factor measurements taken in 1980, 1983, and 1986 in the analyses. Childhood dietary factors and physical activity were assessed by self-reported questionnaires, and a harmonized definition of MetS was used as the adult outcome. Childhood vegetable consumption frequency was inversely associated with adult MetS (odds ratio [OR] 0.86 [95% CI 0.77-0.97], P = 0.02) in a multivariable analysis adjusted with age, sex, childhood metabolic risk factors (lipids, systolic blood pressure, insulin, BMI, and C-reactive protein), family history of type 2 diabetes and hypertension, and socioeconomic status. The association remained even after adjustment for adulthood vegetable consumption. Associations with the other childhood lifestyle factors were not found. Of the individual components of MetS, decreased frequency of childhood vegetable consumption predicted high blood pressure (0.88 [0.80-0.98], P = 0.01) and a high triglyceride value (0.88 [0.79-0.99], P = 0.03) after adjustment for the above-mentioned risk factors. Childhood vegetable consumption frequency is inversely associated with MetS in adulthood. Our findings suggest that a higher intake of vegetables in childhood may have a protective effect on MetS in adulthood.