SQ 30, 957, A NEW ANTIBIOTIC PRODUCED BY PENICILLIUM FUNICULOSUM TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION, SYNTHESIS AND ANTIBACTERIAL ACTIVITY

• Published in: Journal of antibiotics Vol. 39; no. 8; pp. 1054 - 1058
• Main Authors: SINGH, PUSHPA D., JOHNSON, JANICE H., AKLONIS, CAROL A., O'SULLIVAN, JOSEPH
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.08.1986; Japan Antibiotics Research Association
• Subjects: Animals; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics; Bacteria - drug effects; Biological and medical sciences; Biotechnology; Chemical Phenomena; Chemistry; Cyclohexanones - isolation & purification; Cyclohexanones - pharmacology; Fermentation; Fundamental and applied biological sciences. Psychology; General pharmacology; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Medical sciences; Mice; Penicillium - classification; Penicillium - metabolism; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Production of active biomolecules; Fungi; Antibiotic; Taxonomy; Production; Isolation; Fungi Imperfecti; Penicillium funiculosum; Antibacterial agent; Fermentation; Biological activity; Physicochemical properties; Thallophyta
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.39.1054

A new antibiotic, SQ 30, 957, 4-diazo-3-methoxy-2, 5-cyclohexadien-1-one, has been isolated from fermentation broths of Penicillium funiculosum. The structure (1) was deduced from its spectroscopic properties and its degradation reaction. SQ 30, 957 has excellent activity against anaerobic bacteria such as Clostridium and Bacteroides and has moderate activity against aerobic bacteria. The compound has an LD50 of less than 17 mg/kg in mice by intraperitoneal administration.