Direct-from-whole-blood testing will speed sepsis diagnosis

In a recent study published in the Journal of Antimicrobial Chemotherapy, investigators at Lee Health found that patients with potentially deadly infections received targeted therapy 28 hours faster with direct-from-whole-blood tests.2 Using the FDA-cleared direct-from-whole-blood fungal panel, the...

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Bibliographic Details
Published inMLO. Medical laboratory observer Vol. 50; no. 8; pp. 16 - 18
Main Author Lowery, Thomas J
Format Magazine Article Trade Publication Article
LanguageEnglish
Published Nashville Endeavor Business Media 01.08.2018
Subjects
Bacteria
Blood
Blood culture
Blood tests
Care and treatment
Company business management
Cost control
Critical care
Diagnosis
Drug resistance
Drug stores
Economic justification
Health care costs
Hospitals
Identification
Infections
Management
Medical care, Cost of
Medical diagnosis
Medical examination
Patients
Sepsis
Statistics
Systematic review
Florida
United States > US
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Summary:In a recent study published in the Journal of Antimicrobial Chemotherapy, investigators at Lee Health found that patients with potentially deadly infections received targeted therapy 28 hours faster with direct-from-whole-blood tests.2 Using the FDA-cleared direct-from-whole-blood fungal panel, the lab also contributed to the hospital's cost stewardship initiatives and drove savings for the hospital, because faster negative results reduced unnecessary antimicrobial therapy by an average of four days and an estimated cost saving of $280 per patient. Studies have demonstrated that up to 40 percent of patients with bloodstream infections received ineffective empiric therapy.6 The consequences of overuse of unnecessary antimicrobials are significant, from the rise of frightening drug-resistant superbugs identified by the Centers for Disease Control and Prevention (CDC) to immediate patient health impacts such as toxicity. Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus.8 In a prospective pivotal trial that included 11 centers and more than 1,400 subjects, test results were achieved 2.5 days faster than with blood culture with excellent accuracy, including overall average sensitivity of 90 percent and overall average specificity of 98 percent.
ISSN:0580-7247