Implementation and Evaluation of Guillain-Barré Syndrome Surveillance in Puerto Rico during the 2016 Zika Virus Epidemic

• Published in: Puerto Rico health sciences journal Vol. 37; no. Spec Issue; pp. S85 - S92
• Main Authors: Major, Chelsea G, Dirlikov, Emilio, Medina, Nicole A, Lugo-Robles, Roberta, Matos, Desiree, Muñoz-Jordán, Jorge, Colón-Sánchez, Candimar, García-Negrón, Myriam, Olivero-Segarra, Marangely, Malavé-González, Graciela, Thomas, Dana L, Luciano, Carlos A, Waterman, Stephen H, Sejvar, James, Sharp, Tyler M, Rivera-García, Brenda
• Format: Journal Article
• Language: English
• Published: Puerto Rico Universidad de Puerto Rico, Recinto de Ciencias Medicas 01.12.2018
• Subjects: Epidemics; Guillain-Barre Syndrome - diagnosis; Guillain-Barre Syndrome - epidemiology; Guillain-Barre Syndrome - virology; Hospitalization - statistics & numerical data; Humans; Incidence; Population Surveillance - methods; Predictive Value of Tests; Public Health; Puerto Rico - epidemiology; Sensitivity and Specificity; Time Factors; Zika Virus Infection - epidemiology; Puerto Rico; Puerto Rico; Zika virus; Surveillance; Guillain-Barré syndrome
• ISSN: 0738-0658; 2373-6011

Guillain-Barré syndrome (GBS) is an uncommon autoimmune disorder that follows infection or vaccination, and increased incidence has been reported during Zika virus (ZIKV) transmission. During the 2016 ZIKV epidemic, the Puerto Rico Department of Health (PRDH) implemented the Enhanced GBS Surveillance System (EGBSSS). Here, we describe EGBSSS implementation and evaluate completeness, validity, and timeliness. GBS cases were identified using passive surveillance and discharge diagnostic code for GBS. Completeness was evaluated by capture-recapture methods. Sensitivity and positive predictive value (PPV) for confirmed GBS cases were calculated for both case identification methods. Median time to completion of key time steps were compared by quarter (Q1-4) and hospital size. A total of 122 confirmed GBS cases with onset of neurologic illness in 2016 were identified. Capture-recapture methodology estimated that four confirmed GBS cases were missed by both identification methods. Identification of cases by diagnostic code had a higher sensitivity than passive surveillance (89% vs. 80%), but a lower PPV (60% vs. 72%). There was a significant decrease from Q1 to Q3 in median time from hospital admission to case reporting (11 days vs. 2 days, p = 0.032) and from Q2 to Q3 in median time from specimen receipt to arbovirus laboratory test reporting (35 days vs. 26 days, p = 0.004). EGBSSS provided complete, valid, and increasingly timely surveillance data, which guided public health action and supported healthcare providers during the ZIKV epidemic. This evaluation provides programmatic lessons for GBS surveillance and emergency response surveillance.