In vivo evaluation of the potential neurotoxicity of aerosols released from mechanical stress of nano-TiO2 additived paints in mice chronically exposed by inhalation

Engineered Nanomaterials (ENM) provide technical and specific benefits due to their physical-chemical properties at the nanometer scale. For instance, many ENM are used to improve products in the building industry. Nanoscaled titanium dioxide (TiO2) is one of the most used ENM in this industry. Inco...

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Bibliographic Details
Published inJournal of physics. Conference series Vol. 838; no. 1
Main Authors Manixay, S, Delaby, S, Gaie-Levrel, F, Wiart, M, Motzkus, C, Bencsik, A
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.01.2017
Subjects
Air purification
Catalytic activity
Chemical properties
Construction industry
Exposure
Nanomaterials
Nanoparticles
Nerves
Neurotoxicity
Photocatalysis
Physics
Respiration
Sanding
Titanium dioxide
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Summary:Engineered Nanomaterials (ENM) provide technical and specific benefits due to their physical-chemical properties at the nanometer scale. For instance, many ENM are used to improve products in the building industry. Nanoscaled titanium dioxide (TiO2) is one of the most used ENM in this industry. Incorporated in different matrix, cement, glass, paints... TiO2 nanoparticles (NPs) provide the final product with anti-UV, air purification and self-cleaning properties, thanks to their photocatalytic activity. However, ageing processes of such products, as photocatalytic paints, during a mechanical stress have been shown to release TiO2 NPs from this matrix associated with sanding dust. Thus, workers who sand painted walls could be exposed to TiO2 NPs through inhalation. As inhalation may lead to a translocation of particulate matter to the brain via olfactory or trigeminal nerves, there is an urgent need for evaluating a potential neurotoxicity. In order to provide new knowledge on this topic, we developed a dedicated experimental set-up using a rodent model exposed via inhalation. The aerosol released from a mechanical stress of photocatalytic paints containing TiO2 NPs was characterized and coupled to an exposition chamber containing group of mice free to move and chronically exposed (2 hours per day for 5 days a week during 8 weeks).
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/838/1/012025