Modification of kindled amygdaloid seizures by opiate agonists and antagonists
The effects of 19 opiate agonists and antagonists on kindled amygdaloid seizures in the rat were studied. The mu agonists tended to reduce the length of elicited afterdischarges and behavioral ranks, while markedly increasing postictal electroencephalogram spikes and behavioral arrest time. These ef...
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Published in | The Journal of pharmacology and experimental therapeutics Vol. 228; no. 3; pp. 620 - 627 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
American Society for Pharmacology and Experimental Therapeutics
01.03.1984
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Subjects | |
Online Access | Get full text |
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Summary: | The effects of 19 opiate agonists and antagonists on kindled amygdaloid seizures in the rat were studied. The mu agonists
tended to reduce the length of elicited afterdischarges and behavioral ranks, while markedly increasing postictal electroencephalogram
spikes and behavioral arrest time. These effects were reversed by naloxone. The kappa agonists reduced behavioral rank and
variably reduced afterdischarge length with a concomitant lengthening of postictal behavioral arrest time and number of electroencephalogram
spikes. The putative sigma agonist, SKF 10,047, reduced afterdischarge durations only at the higher doses tested. The decreases
found after the sigma agonists in postictal electroencephalogram spiking and time of behavioral arrest were not reversed by
naloxone. Only the lower doses of normeperidine were found to decrease seizure thresholds. The mixed agonist/antagonists (MAA)
cyclazocine and cyclorphan markedly increased seizure threshold and reduced afterdischarge duration and behavioral rank. Only
the MAA pentazocine tended to increase threshold but not suprathreshold afterdischarge durations. The order of ability to
modify the ictal events was MAA (selected) greater than kappa agonists greater than mu agonists greater than sigma agonists.
The increase in postictal events (behavior arrest and spikes) was caused most effectively by pretreatment with mu agonist
greater than kappa agonist greater than selected MAA greater than sigma agonists. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-3565 1521-0103 |