Positive selection through a motif in the alpha beta T cell receptor

The two lineages of T cells, [Alpha][Beta] and [Gamma][Delta], differ in their developmental requirements: only [Alpha][Beta] T cells require major histocompatibility complex recognition, a process known as positive selection. The [Alpha][Beta] T cell receptor (TCR), but not its [Gamma][Delta] count...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 281; no. 5378; pp. 835 - 838
Main Authors Backstrom, B. Thomas, Palmer, Ed
Format Journal Article
LanguageEnglish
Published American Association for the Advancement of Science 07.08.1998
Subjects
Antigen receptors, T cell
Immunologic research
Immunological research
Receptors
T cell antigen receptors
T cells
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Summary:The two lineages of T cells, [Alpha][Beta] and [Gamma][Delta], differ in their developmental requirements: only [Alpha][Beta] T cells require major histocompatibility complex recognition, a process known as positive selection. The [Alpha][Beta] T cell receptor (TCR), but not its [Gamma][Delta] counterpart, contains a motif within the [Alpha]-chain connecting peptide domain ([Alpha]-CPM) that has been conserved over the last 500 million years. In transgenic mice expressing an [Alpha][Beta] TCR lacking the [Alpha]-CPM, thymocytes were blocked in positive selection but could undergo negative selection. Thus, the [Alpha]-CPM seems to participate in the generation of signals required for positive selection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.281.5378.835