Fenofibrate-induced rhabdomyolysis in a patient with stage 4 chronic renal failure due to diabetes mellitus

Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular components into the circulation. Several factors may lead to rhabdomyolysis. Fenofibrate is a fibric acid derivative agent that is used in the treatment of hyperlipidaem...

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Published inJournal of the Pakistan Medical Association Vol. 62; no. 8; pp. 849 - 851
Main Authors Soyoral, Yasemin Usul, Canbaz, Esra Turan, Erdur, Mehmet Fatih, Emre, Habib, Begenik, Huseyin, Erkoc, Reha
Format Journal Article
LanguageEnglish
Published Pakistan Knowledge Bylanes 31.08.2012
Subjects
Care and treatment
Chronic kidney failure
Complications and side effects
Diabetes
Diabetes Mellitus, Type 2 - complications
Diagnosis
Diagnosis, Differential
Female
Fenofibrate
Fenofibrate - adverse effects
Fenofibrate - therapeutic use
Humans
Hypolipidemic Agents - adverse effects
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - diagnosis
Middle Aged
Rhabdomyolysis
Rhabdomyolysis - chemically induced
Rhabdomyolysis - diagnosis
Pakistan
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Summary:Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular components into the circulation. Several factors may lead to rhabdomyolysis. Fenofibrate is a fibric acid derivative agent that is used in the treatment of hyperlipidaemia. Although several case reports of rhabdomyolysis have been reported due to the combination of statin and fenofibrate, fenofibrate alone rarely causes rhabdomyolysis. When administering fenofibrate in chronic renal failure, dose should be adjusted. Here, we report a case with fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0030-9982