Concentrations of oxytetracycline, tetracycline and doxycycline in mandibular osteitis

• Published in: Scandinavian journal of infectious diseases. Supplementum no. 9; p. 37
• Main Authors: Bystedt, H, Dornbusch, K, Nord, C E
• Format: Journal Article
• Language: English
• Published: England 1976
• Subjects: Administration, Oral; Adult; Clinical Trials as Topic; Doxycycline - administration & dosage; Doxycycline - blood; Doxycycline - therapeutic use; Drug Evaluation; Female; Humans; Male; Mandibular Diseases - blood; Mandibular Diseases - drug therapy; Microbial Sensitivity Tests; Middle Aged; Osteitis - blood; Osteitis - drug therapy; Oxytetracycline - administration & dosage; Oxytetracycline - blood; Oxytetracycline - therapeutic use; Tetracycline - administration & dosage; Tetracycline - blood; Tetracycline - therapeutic use
• ISSN: 0300-8878

Treatment of osteitis in the mandible after surgery is still a clinical problem. Levels of three tetracyclines--doxycycline, oxytetracycline and tetracycline--were measured in serum and dental alveolar serum in 30 patients undergoing oral surgery. The serum concentrations were higher than the dental alveolar serum concentrations in all patients. The maximal concentration in the alveolar serum for doxycycline was between 3.0 and 3.5 mug/ml while the corresponding values for oxytetracycline and tetracycline were between 1.0 and 2.0 mug/ml. When the dental alveolar serum concentrations of the various tetracycline analogues were related to their range of inhibitory concentrations for microorganisms isolated from mandibular osteitis, it was found that each drug reached levels sufficient to inhibit most but not all strains.