Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice
The role of feeding schedule on the chronopharmacological aspects of sodium valproate (valproic acid; VPA) was examined. ICR male mice were housed in a 12-hr light and 12-hr dark cycle (lights on at 0700, off at 1900) with food and water ad libitum, under a repeated time restricted feeding (feeding...
Saved in:
Published in | The Journal of pharmacology and experimental therapeutics Vol. 278; no. 1; pp. 74 - 81 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.07.1996
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The role of feeding schedule on the chronopharmacological aspects of sodium valproate (valproic acid; VPA) was examined. ICR
male mice were housed in a 12-hr light and 12-hr dark cycle (lights on at 0700, off at 1900) with food and water ad libitum,
under a repeated time restricted feeding (feeding time: 0900-1700) for 2 wk, under fasting for 12 hr or under fasting for
12 hr and feeding for 2 hr before the experiment. VPA was used at an i.p. dose of 1200 mg/kg for toxicity, an oral dose of
600 mg/kg for electroshock seizure threshold and plasma VPA concentration, an i.v. dose of 50 mg/kg for pharmacokinetic study
and at a rate of 1072.6 micrograms/hr for constant-rate administration using an osmotic minipump. The toxicity, electroshock
seizure threshold and VPA concentration (probably at the absorption phase) were significantly higher in the light and lower
in the dark showing rhythmicity. The rhythmicity in VPA concentration during constant-rate administration was related to that
of clearance and volume of distribution. The rhythms of electroshock seizure threshold and VPA absorption were controlled
easily by the temporal manipulation of feeding schedule, but the rhythms of toxicity, clearance and volume of distribution
were not. The manipulation of the feeding schedule and the choice of the most appropriate time of day for drug administration
may help to achieve rational chronotherapeutics of some drugs including VPA in certain experimental and clinical situations. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0022-3565 1521-0103 |