Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis

• Published in: Annals of allergy Vol. 57; no. 2; p. 133
• Main Authors: Chudwin, D S, Strub, M, Golden, H E, Frey, C, Richmond, G W, Luskin, A T
• Format: Journal Article
• Language: English
• Published: United States 01.08.1986
• Subjects: Albuterol - therapeutic use; Arthritis, Rheumatoid - drug therapy; Asthma - drug therapy; Bronchial Spasm - chemically induced; Bronchial Spasm - drug therapy; Choline - adverse effects; Choline - analogs & derivatives; Drug Combinations - adverse effects; Drug Hypersensitivity - etiology; Female; Humans; Middle Aged; Nasal Polyps - drug therapy; Salicylates - adverse effects; Tartrazine - adverse effects; Urticaria - chemically induced
• ISSN: 0003-4738

A woman experienced exacerbations of bronchial asthma after taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis. On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate. Non-acetylated salicylates have been recommended for use in aspirin- and/or tartrazine-sensitive patients. The results of sensitivity studies of our patient indicates that such patients may also be sensitive to non-acetylated salicylates.