Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis

A woman experienced exacerbations of bronchial asthma after taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis. On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid...

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Bibliographic Details
Published inAnnals of allergy Vol. 57; no. 2; p. 133
Main Authors Chudwin, D S, Strub, M, Golden, H E, Frey, C, Richmond, G W, Luskin, A T
Format Journal Article
LanguageEnglish
Published United States 01.08.1986
Subjects
Albuterol - therapeutic use
Arthritis, Rheumatoid - drug therapy
Asthma - drug therapy
Bronchial Spasm - chemically induced
Bronchial Spasm - drug therapy
Choline - adverse effects
Choline - analogs & derivatives
Drug Combinations - adverse effects
Drug Hypersensitivity - etiology
Female
Humans
Middle Aged
Nasal Polyps - drug therapy
Salicylates - adverse effects
Tartrazine - adverse effects
Urticaria - chemically induced
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Summary:A woman experienced exacerbations of bronchial asthma after taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis. On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate. Non-acetylated salicylates have been recommended for use in aspirin- and/or tartrazine-sensitive patients. The results of sensitivity studies of our patient indicates that such patients may also be sensitive to non-acetylated salicylates.
ISSN:0003-4738