Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model

Peripheral nerve injury is a common condition with a multitude of signs and symptoms. The major consequence of injury is limited physical activity. Presently, we are lacking effective therapies for PNI and it is need of the hour is to explore potential remedies for the recovery of functional loss. H...

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Published inPakistan journal of pharmaceutical sciences Vol. 32; no. 2 (Supplementary); pp. 785 - 792
Main Authors Aziz, Nimra, Rasul, Azhar, Malik, Shoaib Ahmad, Anwar, Haseeb, Imran, Ali, Razzaq, Aroona, Shaukat, Arslan, Shahid Kamran, Syed Kashif, de Aguilar, Jose-Luis Gonzalez, Sun, Tao, Hussain, Ghulam
Format Journal Article
LanguageEnglish
Published Pakistan Pakistan Journal of Pharmaceutical Sciences 01.03.2019
Subjects
Analysis
Animals
Blood Glucose
Body Weight
Cannabis
Dietary Supplements
Disease Models, Animal
Eating
Exercise
Grip strength
Health aspects
Hemoglobins
Life Sciences
Male
Marijuana
Mice
Motor Activity
Neurophysiology
Oxidative Stress
Peripheral Nerve Injuries
Peripheral nerves
Physical fitness
Plant Leaves
Powders
Recovery of Function
Sciatic Nerve
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Summary:Peripheral nerve injury is a common condition with a multitude of signs and symptoms. The major consequence of injury is limited physical activity. Presently, we are lacking effective therapies for PNI and it is need of the hour is to explore potential remedies for the recovery of functional loss. Here, we have investigated the role of crude Cannabis sativa L. leaf powder in promoting functions recovery, in mouse model subjected to a traumatic sciatic nerve injury. A dose of 200mg/kg of the body weight per day was administered orally from the day of nerve crush till the end of the experiment. The motor functions were evaluated by measuring sciatic functional index, muscle grip strength and muscle mass; whereas the sensory functions were assessed by hotplate test. The haematology and serum analyses were carried out to estimate the effect of treatment on the systemic index and oxidative stress. The gain of motor functions was significantly improved and was early noticed in the treated mice. Restoration of muscle mass and elevated haemoglobin level were statistically significant in the treatment group. This study indicates that Cannabis sativa L. supplementation accelerates the motor functions recovery after nerve compression injury.
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ISSN:1011-601X