Elemental F2 with Transannular Dienes: Regioselectivities and Mechanisms
Three reaction paths, namely, molecule‐induced homolytic, free radical, and electrophilic, were modeled computationally at the MP2 level of ab initio theory and studied experimentally for the reaction of F2 with the terminal dienes of bicyclo[3.3.1]nonane series. The addition of fluorine is accompan...
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Published in | Chemistry : a European journal Vol. 20; no. 33; pp. 10383 - 10391 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
11.08.2014
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Three reaction paths, namely, molecule‐induced homolytic, free radical, and electrophilic, were modeled computationally at the MP2 level of ab initio theory and studied experimentally for the reaction of F2 with the terminal dienes of bicyclo[3.3.1]nonane series. The addition of fluorine is accompanied by transannular cyclization to the adamantane derivatives in which strong evidence for the electrophilic mechanism both in nucleophilic (acetonitrile) and non‐nucleophilic (CFCl3, CHCl3) solvents were found. The presence of KF in CFCl3 and CHCl3 facilitates the addition and substantially reduces the formation of tar products.
Modeling fluorination mechanisms: Molecule‐induced homolytic, free radical, and electrophilic paths were modeled computationally at the MP2 level of ab initio theory and studied experimentally for the reaction of F2 with dienes of the bicyclo[3.3.1]nonane series (see scheme). Strong evidence for the electrophilic addition of elementary fluorine both in nucleophilic (acetonitrile) and non‐nucleophilic (CFCl3/CHCl3) solvents were found. |
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Bibliography: | Ministry of Science and Education of Ukraine ark:/67375/WNG-S8JD8G92-M ArticleID:CHEM201402640 istex:D76C122DDD5A4A20F4B6CFD2FE5DDDE6DE5A0BF5 Ukrainian Basic Research Foundation ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.201402640 |