Flurbiprofen axetil: Analgesic effect and adverse reaction

Flurbiprofen axetil is a targeted analgesic and non steroidal analgesic with lipid microspheres as drug carrier. It can selectively accumulate in surgical incision and reduce the allodynia a caused by surgical trauma. In this paper, the experimental subjects were divided into three groups to analyze...

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Bibliographic Details
Published inPakistan journal of pharmaceutical sciences Vol. 31; no. 3(Special); p. 1163
Main Authors Zhao, Xiaodong, Ji, Leting
Format Journal Article
LanguageEnglish
Published Pakistan Pakistan Journal of Pharmaceutical Sciences 01.05.2018
Subjects
Analgesics
Dosage and administration
Drug delivery systems
Flurbiprofen
Health aspects
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Summary:Flurbiprofen axetil is a targeted analgesic and non steroidal analgesic with lipid microspheres as drug carrier. It can selectively accumulate in surgical incision and reduce the allodynia a caused by surgical trauma. In this paper, the experimental subjects were divided into three groups to analyze the difference in the analgesic effect of different doses of flurbiprofen axetil for postoperative analgesia. The patients in group A, B and C were treated with flurbiprofen axetil injection 100, 150, 200mg, respectively. The results showed that MAP, HR, static and dynamic VAS scores and postoperative pain incidence in group B and group C were lower than those in group A, and B group had better analgesic effect and lower incidence of adverse reactions. In the future, we should continue to explore the correlation between the effect of flurbiprofen axetil for postoperative analgesia on coagulation function and the range of dose safety.
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ISSN:1011-601X