Effectiveness evaluation of cardiovascular drugs based on CYP2C9 target protein

This study is to discuss the effectiveness evaluation of cardiovascular drugs based on CYP2C9 target protein. Multilevel fuzzy comprehensive evaluation method was taken to evaluate the individualized medication effectiveness for cardiovascular drug under the function of CYP2P9 target protein. Then,...

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Published inPakistan journal of pharmaceutical sciences Vol. 28; no. 4 Suppl; pp. 1545 - 1549
Main Authors Guo, Guoxun, Zhao, Youmin, Chai, Jianwen, Hao, Dongqin, Song, Fukai
Format Journal Article
LanguageEnglish
Published Pakistan Pakistan Journal of Pharmaceutical Sciences 01.07.2015
Subjects
Cardiovascular agents
Cardiovascular Agents - therapeutic use
Cytochrome P-450
Cytochrome P-450 CYP2C9 - genetics
Drug metabolism
Fuzzy Logic
Genetic aspects
Humans
Innovations
Molecular targeted therapy
Properties
Testing
Tetrazoles - therapeutic use
Valine - analogs & derivatives
Valine - therapeutic use
Valsartan
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Summary:This study is to discuss the effectiveness evaluation of cardiovascular drugs based on CYP2C9 target protein. Multilevel fuzzy comprehensive evaluation method was taken to evaluate the individualized medication effectiveness for cardiovascular drug under the function of CYP2P9 target protein. Then, it was established for the index system to affect drug efficacy and index weight was settled. This index system was applied on the study of valsartan drugs to evaluate the drug efficacy rate of sample. Results corresponded with the actual drug treatment, and received better verification. The beneficial exploration was performed for the effectiveness evaluation of individualized administration.
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ISSN:1011-601X