Alkaloid and phenolic compounds of Xylopia aromatica inhibits tumor growth by down-regulating matrix metalloproteinase-2 (MMP-2) expression

• Published in: Pakistan journal of pharmaceutical sciences Vol. 34; no. 2; pp. 599 - 606
• Main Authors: Gomes, Izabela Natalia Faria, Silva, Ana Gabriela, Frazao Lima, Gustavo Fernando de, Longatti, Tamara Ribeiro, Do Carmo, Lucas Fernandes, Villar, Jose Augusto Ferreira Perez, Araujo, Arali Aparecida Da Costa, Tome, Ralph Gruppi, Santos, Helio Batista Dos, Azambuja Ribeiro, Rosy Iara Maciel De
• Format: Journal Article
• Language: English
• Published: Pakistan Pakistan Journal of Pharmaceutical Sciences 01.03.2021
• Subjects: Alkaloids; Alkaloids - chemistry; Animals; Aporphines - chemistry; Bioflavonoids; Cancer; Carcinoma, Ehrlich Tumor - metabolism; Carcinoma, Ehrlich Tumor - pathology; Care and treatment; Catechin - chemistry; Cell Line, Tumor; Cell Proliferation - drug effects; Chlorogenic Acid - chemistry; Chromatography, High Pressure Liquid; Down-Regulation; Flavones; Flavonoids; Flavonoids - chemistry; Gallic Acid - chemistry; Growth; High performance liquid chromatography; Lymphocytes, Tumor-Infiltrating - drug effects; Matrix Metalloproteinase 2 - drug effects; Matrix Metalloproteinase 2 - metabolism; Medicine, Botanic; Medicine, Herbal; Mice; Necrosis; Penicillin G; Phenols - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves; Plant metabolites; Quercetin - chemistry; Rutin - chemistry; Statistics; Tumor Burden - drug effects; Tumors; Xylopia; Brazil

Annonacea species have been reported to possess antitumor properties. However, the in vitro and in vivo antitumor activities of Xylopia aromatica (Annonacea) have not yet been elucidated. This study aimed to investigate the effects of Xylopia aromatica leaves hexane fraction (XaHF) on Ehrlich ascite...