Authentication of various commercially available crude drugs using different quality control testing parameters

• Published in: Pakistan journal of pharmaceutical sciences Vol. 33; no. 4; pp. 1641 - 1657
• Main Authors: Fatima, Kaneez, Mahmud, Shaukat, Yasin, Hina, Asif, Rana, Qadeer, Kiran, Ahmad, Iqbal
• Format: Journal Article
• Language: English
• Published: Pakistan Pakistan Journal of Pharmaceutical Sciences 01.07.2020
• Subjects: Chromatography; Herbal medicine; Infrared spectroscopy; Quality control; Quality management; Raw materials; United Kingdom; Pakistan; India
• ISSN: 1011-601X
• DOI: 10.36721/PJPS.2020.33.4.REG.1641-1657.1

The object of this study is to investigate the quality of various plant materials used in the preparation of herbal formulations using different methods of standardization to confirm their purity, safety and efficacy. However, it is uncertain whether these raw materials comply with the standards prescribed in the pharmacopeias. In the present study six raw materials' i.e. Foeniculum vulgarae, Curcuma longa, Aloe barbadensis, Plantago ovata, Zingiber officinale and Glycyrrhiza glabra have been obtained from the market and various quality control tests including microscopic evaluation, physico-chemical characteristics, thin layer chromatography (TLC), spectrophotometric assay (British Pharmacopoeia) and Fourier transform infrared spectroscopy (FTIR) have been performed to determine their compliance with the standards. The TLC has been used for the identification of the active ingredients on comparison of their R values with the reference standard. FTIR Spectra of these materials have been obtained to assign the functional groups present in the components of a particular material. Although these findings provide a significant data to herbal drug manufacturers for authentication of commercially available plant materials used in various herbal formulation.