Long-lasting hypothermic effects of vincristine in rats

The effects of vincristine given intravenously on deep and superficial body temperature were assessed in rats kept at ambient temperature within the thermoneutral range. Vincristine (0.5 and 1 mg/kg i.v.) produced a gradual but marked hypothermic response which was dose-dependent, reached its maximu...

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Bibliographic Details
Published inArchives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Vol. 7; p. 500
Main Authors Rotiroti, D, Naccari, F, Ammendola, D, Gratteri, S, De Gori, N, Nisticò, G
Format Journal Article
LanguageEnglish
Published Germany 1984
Subjects
Animals
Body Temperature - drug effects
Male
Phentolamine - pharmacology
Rats
Rats, Inbred Strains
Time Factors
Vincristine - antagonists & inhibitors
Vincristine - toxicity
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Summary:The effects of vincristine given intravenously on deep and superficial body temperature were assessed in rats kept at ambient temperature within the thermoneutral range. Vincristine (0.5 and 1 mg/kg i.v.) produced a gradual but marked hypothermic response which was dose-dependent, reached its maximum after approximately 3 h and lasting approximately 48 h. Vincristine induced a decrease in deep body temperature which was accompanied by piloerection and a decrease in skin temperature. Pretreatment with phentolamine, an alpha-adrenoceptor blocking agent (0.5 mg/kg i.v. 15 min before) prevented the hypothermic effects induced by subsequent administration of vincristine (0.5 mg/kg i.v.). These experiments showed that vincristine produced a marked hypothermic response in rats. However, the precise site of action remains to be established.
ISSN:0171-9750
DOI:10.1007/978-3-642-69132-4_106