Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells

Liver cirrhosis is the end stage of chronic liver disease, and the only radical treatment for decompensated liver cirrhosis is still liver transplantation. Development of effective regenerative therapy for liver cirrhosis is an urgent task. Before human clinical trials can be considered, the safety...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1905; p. 201
Main Authors Takami, Taro, Tani, Kenji, Taura, Yasuho, Sakaida, Isao
Format Journal Article
LanguageEnglish
Published United States 2019
Subjects
Animals
Bone Marrow Cells - cytology
Bone Marrow Transplantation - methods
Carbon Tetrachloride - adverse effects
Cells, Cultured
Disease Models, Animal
Dogs
Humans
Injections
Liver Cirrhosis - chemically induced
Liver Cirrhosis - therapy
Male
Transplantation, Autologous
Canine model
Liver cirrhosis
Carbon tetrachloride
Mesenchymal stem cells
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Summary:Liver cirrhosis is the end stage of chronic liver disease, and the only radical treatment for decompensated liver cirrhosis is still liver transplantation. Development of effective regenerative therapy for liver cirrhosis is an urgent task. Before human clinical trials can be considered, the safety and efficacy of any planned protocol must be confirmed in medium-to-large animals. Therefore, we have developed a novel canine liver fibrosis model for proof of concept (POC) studies.
ISSN:1940-6029
DOI:10.1007/978-1-4939-8961-4_18