Opioid-induced hyperalgesia : A qualitative systematic review

Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, o...

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Bibliographic Details
Published inAnesthesiology (Philadelphia) Vol. 104; no. 3; pp. 570 - 587
Main Authors ANGST, Martin S, CLARK, J. David
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott 01.03.2006
Subjects
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Humans
Hyperalgesia - chemically induced
Medical sciences
Opioid-Related Disorders - complications
Anesthesia
Hyperalgesia
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Summary:Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning opioid-induced hyperalgesia, suggests a framework for organizing pertinent information, delineates the status quo of our knowledge, identifies potential clinical implications, and discusses future research directions.
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-200603000-00025