Neurosurgery Functional regeneration after laser axotomy

Understanding how nerves regenerate is an important step towards developing treatments for human neurological disease, but investigation has so far been limited to complex organisms (mouse and zebrafish) in the absence of precision techniques for severing axons (axotomy). Here we use femtosecond las...

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Bibliographic Details
Published inNature Vol. 432; no. 7019; p. 822
Main Authors Ben-Yakar, Adela, Yanik, Mehmet Fatih, Cinar, Hulusi, Cinar, Hediye Nese, Chisholm, Andrew D, Jin, Yishi
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 16.12.2004
Subjects
Animals
Axons - physiology
Axotomy
Caenorhabditis elegans
Caenorhabditis elegans - cytology
Caenorhabditis elegans - growth & development
Caenorhabditis elegans - physiology
Larva - cytology
Larva - physiology
Laser Therapy - methods
Locomotion - physiology
Motor Neurons - cytology
Motor Neurons - physiology
Nerve Regeneration - physiology
Neurosurgery
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Summary:Understanding how nerves regenerate is an important step towards developing treatments for human neurological disease, but investigation has so far been limited to complex organisms (mouse and zebrafish) in the absence of precision techniques for severing axons (axotomy). Here we use femtosecond laser surgery for axotomy in the roundworm Caenorhabditis elegans and show that these axons functionally regenerate after the operation. Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form.
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ISSN:0028-0836
1476-4687
DOI:10.1038/432822a