Antiepileptic therapy and teratogenicity in Turkey

In this study 170 children born to 116 epileptic mothers are evaluated for the presence of congenital malformations. In one group, the mothers of 104 children were administered with one or more antiepileptic drugs (AEDs) during their pregnancies. In the control group, the mothers of 66 children rece...

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Bibliographic Details
Published inInternational journal of clinical pharmacology, therapy, and toxicology Vol. 30; no. 8; p. 261
Main Authors Eşkazan, E, Aslan, S
Format Journal Article
LanguageEnglish
Published Germany 01.08.1992
Subjects
Abnormalities, Drug-Induced - epidemiology
Abnormalities, Drug-Induced - etiology
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Child
Child, Preschool
Epilepsy - drug therapy
Female
Humans
Incidence
Pregnancy
Pregnancy Complications - drug therapy
Pregnancy Trimester, First
Prospective Studies
Turkey - epidemiology
Turkey
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Summary:In this study 170 children born to 116 epileptic mothers are evaluated for the presence of congenital malformations. In one group, the mothers of 104 children were administered with one or more antiepileptic drugs (AEDs) during their pregnancies. In the control group, the mothers of 66 children received no therapy throughout or during the first trimester of their pregnancies. Twelve of the 104 children who were exposed to antiepileptic drugs in utero, had various major congenital malformations. On the other hand, 66 children who were not exposed to AEDs in utero had no malformations. The incidence of congenital malformations in children born to epileptic mothers was found to be significantly higher compared to the incidence observed in other studies (0.48-2%) among the general population of Turkey.
ISSN:0174-4879