Nephrocalcinosis in the rat: a literature review

Nephrocalcinosis is a common disorder in female rats. Various etiological factors are involved in the pathogenesis, e.g. sex, age, genetical and dietary factors. Dietary phosphorus concentration appears to be of crucial importance in the induction of nephrocalcinosis. The pathological changes in cal...

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Bibliographic Details
Published inProgress in food and nutrition science Vol. 16; no. 1; p. 85
Main Authors Ritskes-Hoitinga, J, Beynen, A C
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Age Factors
Animals
Diet
Female
Male
Minerals - metabolism
Nephrocalcinosis - etiology
Nephrocalcinosis - physiopathology
Rats
Sex Factors
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Summary:Nephrocalcinosis is a common disorder in female rats. Various etiological factors are involved in the pathogenesis, e.g. sex, age, genetical and dietary factors. Dietary phosphorus concentration appears to be of crucial importance in the induction of nephrocalcinosis. The pathological changes in calcinotic kidney tissue are described. Possible mechanisms underlying nephrocalcinogenesis are discussed. Phosphorus concentration within the proximal tubule may be the major determinant of nephrocalcinogenesis.
ISSN:0306-0632