Changes in androgens during treatment with four low-dose contraceptives

• Published in: Contraception (Stoneham) Vol. 53; no. 3; pp. 171 - 176
• Main Authors: COENEN, C. M. H, THOMAS, C. M. G, BORM, G. F, HOLLANDERS, J. M. G, ROLLAND, R
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 01.03.1996
• Subjects: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androgens - blood; Androstenedione - blood; Biological and medical sciences; Birth control; Contraceptives, Oral, Combined - administration & dosage; Contraceptives, Oral, Combined - adverse effects; Dehydroepiandrosterone - analogs & derivatives; Dehydroepiandrosterone - blood; Dehydroepiandrosterone Sulfate; Desogestrel - administration & dosage; Desogestrel - adverse effects; Dihydrotestosterone - blood; Ethinyl Estradiol - administration & dosage; Ethinyl Estradiol - adverse effects; Ethinyl Estradiol-Norgestrel Combination - analogs & derivatives; Female; Gynecology. Andrology. Obstetrics; Hormonal contraception; Humans; Hydroxyprogesterones - blood; Luteal Phase; Medical sciences; Norgestrel - administration & dosage; Norgestrel - adverse effects; Norgestrel - analogs & derivatives; Norpregnenes - administration & dosage; Norpregnenes - adverse effects; Pancuronium - administration & dosage; Pancuronium - adverse effects; Pancuronium - analogs & derivatives; Progestins - administration & dosage; Progestins - adverse effects; Sex Hormone-Binding Globulin - metabolism; Testosterone - blood; Transcortin - metabolism; Human; Estroprogestagen; Androgen; Low dose; Oral administration; Female; Androgen hormone; Contraceptive; Sex steroid hormone; Comparative study; Comparative Studies; Biology; Hormones; Research Methodology; Dermatitis; Saudi Arabia; Netherlands; Oral Contraceptives, Low-dose; Western Asia; Contraceptive Methods; Research Report; Physiology; Oral Contraceptives; Arab Countries; Acne; Europe; Hirsutism; Contraception; Family Planning; Endocrine System; Diseases; Western Europe; Studies; Androgens; Developed Countries; Asia; Signs And Symptoms; Developing Countries
• ISSN: 0010-7824; 1879-0518
• DOI: 10.1016/0010-7824(96)00006-6

The aim of the present study was to compare changes in the endogenous androgen environment in healthy women while on low-dose oral contraceptives (OCs). One-hundred healthy women were randomized to receive one of four OCs during six months: 21 tablets of Cilest, Femodeen, Marvelon, or Mercilon. During the luteal phase of the pretreatment cycle, body weight and blood pressure were recorded and the following parameters were measured: sex hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG), testosterone (T), free testosterone (FT), 5 alpha-dihydrotestosterone (DHT), androstenedione (A), dehydroepiandrosterone-sulphate (DHEA-S) and 17 alpha-hydroxyprogesterone (170HP) while also the free androgen index (FAI) was calculated. Measurements were repeated during the 3rd week of pill intake in the 4th and the 6th pill month. There were no differences on body mass and blood pressure with the use of the four OCs. The mean serum DHEA-S decreased significantly in all groups though less in the Mercilon group when compared to Cilest and Marvelon (approximately 20% vs 45%). Mean serum SHBG and CBG increased significantly in all four groups approximately 250% and 100%, respectively. In each group CBG also increased significantly but less in women taking Mercilon (-75%) as compared to the others (-100%). Current low-dose OCs were found to have similar impact on the endogenous androgen metabolism with significant decreases of serum testosterone, DHT, A, and DHEA-S. They may be equally beneficial in women with androgen related syndromes such as acne and hirsutism.