Effect of Resveratrol on Fatty Acid Compositions and Lipophilic Vitamins of Fructose Induced Nonalcoholic Fatty Liver

• Published in: Pakistan journal of zoology Vol. 49; no. 6; p. 2103
• Main Authors: Guvenc, Mehmet, Guvenc, Ayse Nilay, Ylmaz, Okkes, Tuzcu, Mehmet
• Format: Journal Article
• Language: English
• Published: Lahore Knowledge Bylanes 31.12.2017; AsiaNet Pakistan (Pvt) Ltd
• Subjects: Causes of; Cholesterol; Chromatography; Diet; Drinking behavior; Drinking water; Fatty acids; Fatty liver; Fructose; Health aspects; Herbal medicine; Lipid peroxidation; Lipids; Lipophilic; Liver cancer; Liver diseases; Low density lipoprotein receptors; Metabolic syndrome; Oxidative stress; Polyphenols; Rats; Resveratrol; Rodents; Vitamin A; Vitamin D3; Vitamins
• ISSN: 0030-9923
• DOI: 10.17582/journal.pjz/2017.49.6.2103.2111

In this study, the effect of resveratrol on the liver of rats induced by fructose was investigated. Adult male Winstar rats were randomly divided into four groups; control, resveratrol, fructose, and resveratrol plus fructose. Resveratrol was administered 30 mg/kg intraperitoneally. Fructose (10% w/v) was administered with drinking water for 56 days every alternate day. Fructose administration increased the hepatic omega-6/omega-3 and 16:1 n7 / 16:0 ratios (p < 0.001, p < 0.001), but decreased the retinol and alfa tocoferol levels (p < 0.01) compared with control group. Resveratrol administration to fructose treated rats decreased the retinol and cholesterol levels (p < 0.01, p < 0.05), and increased alfa tocoferol and vitamin d3 levels (p < 0.01) in the liver. Our results suggest that resveratrol act as a bioregulator for some biochemical parameters in fructose induced non-alcoholic fatty liver.