Chromosome aberrations in patients irradiated for pelvic tumours

Peripheral blood lymphocytes of patients undergoing radiation therapy for pelvic tumours have been examined for the presence of dicentric and centric ring chromosomes. Blood samples were taken, by venipuncture, prior to the first radiotherapy session and 24 h after radiotherapy sessions to allow the...

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Bibliographic Details
Published inStrahlentherapie und Onkologie Vol. 163; no. 12; p. 795
Main Authors Léonard, A, Decat, G, Léonard, E D, Wambersie, A, Renard, J
Format Journal Article
LanguageEnglish
Published Germany 01.12.1987
Subjects
Adenocarcinoma - genetics
Adenocarcinoma - radiotherapy
Breast Neoplasms - genetics
Breast Neoplasms - radiotherapy
Carcinoma - genetics
Carcinoma - radiotherapy
Chromosome Aberrations
Dose-Response Relationship, Radiation
Female
Humans
Male
Pelvic Neoplasms - genetics
Pelvic Neoplasms - radiotherapy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - radiotherapy
Spondylitis, Ankylosing - genetics
Spondylitis, Ankylosing - radiotherapy
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - radiotherapy
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Summary:Peripheral blood lymphocytes of patients undergoing radiation therapy for pelvic tumours have been examined for the presence of dicentric and centric ring chromosomes. Blood samples were taken, by venipuncture, prior to the first radiotherapy session and 24 h after radiotherapy sessions to allow the mixing of the irradiated lymphocytes in the circulating blood. The yield of dicentrics and centric rings was best fitted by a straight line which, according the maximum likelihood method, corresponds to Y = 1.77 +/- 0.0003 10(-2) D. On this basis the dose inducing ten dicentrics or rings is 5.62 Gy at the target volume and, thus, is intermediate between the doses at the target volumes displaying the same effects in patients treated for mammary carcinoma (15 Gy) or for ankylosing spondylitis (2 Gy).
ISSN:0179-7158