Antinociceptive and anti-pyretic activity of Benincasa hispida (thunb.) cogn. in Wistar albino rats

The seeds of Benincasa hispida (Thunb) COGN. (Family: Cucurbitaceae) was extracted with ethanol and was used to study acute toxicity, antinociceptive and anti-pyretic effects. Brewer's yeast (15%) was used to induce pyrexia in rats. The extract was non lethal to the rats up to the dose of 5000...

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Bibliographic Details
Published inPakistan journal of pharmaceutical sciences Vol. 22; no. 3; p. 287
Main Authors Qadrie, Zulfkar Latief, Hawisa, Najat Tayeb, Khan, Mohd Wajid Ali, Samuel, Moses, Anandan, R
Format Journal Article
LanguageEnglish
Published Pakistan Pakistan Journal of Pharmaceutical Sciences 01.07.2009
Subjects
Analgesics
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - pharmacology
Analgesics, Non-Narcotic - therapeutic use
Animals
Body Temperature - drug effects
Crop yields
Cucurbitaceae
Diclofenac
Dose-Response Relationship, Drug
Fever - chemically induced
Fever - drug therapy
Male
Medicine, Botanic
Medicine, Herbal
Pain - drug therapy
Pain Measurement
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Saccharomyces cerevisiae
Seeds
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Summary:The seeds of Benincasa hispida (Thunb) COGN. (Family: Cucurbitaceae) was extracted with ethanol and was used to study acute toxicity, antinociceptive and anti-pyretic effects. Brewer's yeast (15%) was used to induce pyrexia in rats. The extract was non lethal to the rats up to the dose of 5000 mg/kg b.w. At doses of 250 and 500 mg/kg b.w, the extract significantly (P<0.05) increased the antinociceptive effective in a dose dependent manner in rats. Similarly, at doses of 250 and 500 mg/kg b.w the extract significantly (P<0.05) decreased yeast-induced pyrexia in rats. These results indicate that ethanolic extract of Benincasa hispida possesses potent antinociceptive and antipyretic effects and thus pharmacologically justifying its folkloric use in the management of fever and pain conditions.
ISSN:1011-601X