Environmentally benign synthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using CeO2 nanoparticles as a reusable and robust catalyst

In this work, we report the synthesis and characterization of CeO nanoparticles as an efficient catalyst for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3- ]pyrazole-3-carboxylates via one-pot four-component condensation reaction of dimethyl acetylenedicarboxylate, hydrazine...

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Published inZeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 71; no. 11; pp. 1135 - 1140
Main Authors Safaei-Ghomi, Javad, Asgari-Kheirabadi, Mehrnoosh, Shahbazi-Alavi, Hossein
Format Journal Article
LanguageEnglish
Published BERLIN De Gruyter 01.11.2016
Walter De Gruyter
Subjects
catalytic activity
CeO
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
multicomponent reactions
nanoparticles
one-pot
Physical Sciences
pyrano[2,3
pyrazole
Science & Technology
one-pot
multicomponent reactions
AQUEOUS-MEDIUM
CeO2 nanoparticles
PYRANOPYRAZOLES
nanoparticles
catalytic activity
CERIA
pyrano[2,3-c]pyrazole
DERIVATIVES
EFFICIENT
MULTICOMPONENT REACTION
WATER
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Summary:In this work, we report the synthesis and characterization of CeO nanoparticles as an efficient catalyst for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3- ]pyrazole-3-carboxylates via one-pot four-component condensation reaction of dimethyl acetylenedicarboxylate, hydrazine hydrate, malononitrile, and aldehydes in aqueous medium. The use of a non-hazardous organic solvent, easy recovery of the catalyst, compatibility with various functional groups, and high yield of the products make the protocol attractive, greener, and economic.
ISSN:0932-0776
1865-7117
DOI:10.1515/znb-2016-0119