Diabetic peripheral neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats

Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT r...

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Published inJournal of veterinary medical science Vol. 74; no. 12; pp. 1669 - 1673
Main Authors Yamaguchi, Takayuki, Sasase, Tomohiko, Mera, Yasuko, Tomimoto, Daisuke, Tadaki, Hironobu, Kemmochi, Yusuke, Ohta, Takeshi, Sato, Eimei, Matsushita, Mutsuyoshi
Format Journal Article
LanguageEnglish
Published Japan 01.12.2012
Subjects
Animals
Blood Glucose - drug effects
Body Weight
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Neuropathies - physiopathology
Disease Models, Animal
Insulin - blood
Male
Motor Neurons - physiology
Neural Conduction - physiology
Pioglitazone
Rats
Rats, Sprague-Dawley
Rats, Zucker
Sural Nerve - cytology
Thiazolidinediones - pharmacology
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Summary:Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.
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ISSN:1347-7439
DOI:10.1292/jvms.12-0149