In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: 3D bioprinting; animal models; Biology, life sciences; cancer stem cell methods; cancer stem cells; cancer-on-chip; CDX2; chromosomal instability; circulating tumor cells; clinical translation study; clinical trials; colon cancer; colorectal cancer; colorectal carcinoma; CRC; CTC cluster; decitabine; DNA damage; DNA methylation; drug combination; drug resistance; epithelial mesenchymal transition; HIF-1α; histological examination; hypoxia; immunofluorescence analysis; immunotherapy; in vitro culture; machine learning; Mathematics and Science; methods; Microbiology (non-medical); mutation analysis; organoids; patient-derived cancer models; patient-derived tumor organoid; patient-derived xenograft; PDX model; precision medicine; prognosis; radiation response; rectal cancer; Reference, Information and Interdisciplinary subjects; Research and information: general; SATB2; ScreenCell; sequential filtration; single-cell RNA-sequencing; size-based method; targeted therapy; transcriptional programs; tumor cell differentiation; tumor heterogeneity; tumor metabolism; tumor-initiating cells
• ISBN: 9783036539652; 3036539662; 9783036539669; 3036539654
• DOI: 10.3390/books978-3-0365-3965-2

The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC.