REPRODUCTION STUDY ON CEFUROXIME AXETIL (CXM-AX)(IV) TERATOLOGICAL STUDY IN RABBITS

• Published in: CHEMOTHERAPY Vol. 34; no. Supplement5; pp. 271 - 279
• Main Authors: FURUHASHI, TADAKAZU, MIYOSHI, KOJI, NAKAYOSHI, HIROSHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1986
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.34.Supplement5_271

Teratological study on cefuroxime axetil (CXM-AX, SN 407), a newly developed cephalosporin antibiotic, was carried out in New Zealand White rabbits. CXNI-AX was administered orally to female rabbits from day 6 to day 18 of gestation at daily doses of 7.5, 15 and 30mg/kg. Four dams in 15mg/kg dose group and 8 dams in 30mg/kg dose group died. Food and water consumptions decreased in the live dams in 30mg/kg group. In necropsy on day 29 of gestation, increase in weight of cecum at doses of 15mg/kg or more, and decreases in weights of the carcass and kidneys and increase in weight of thymus at dose of 30mg/kg were observed. Decrease in fetal viability was observed in 15mg/kg group or more, and decrease in fetal body weight, body length and tail length were observed in 30mg/kg group. There were no effects on the number of live fetuses, sex ratio, and incidence of embryonic death or anomaly. Thus, in the present study, maximum no-effect dose level of CXM-AX on dams and fetuses was estimated to be 7.5mg/kg, and no teratological changes were detected in fetuses treated with CNM AX at dose of 30mg/kg.