A Nash Equilibrium Approach to Metabolic Network Analysis

• Published in: Machine Learning, Optimization, and Big Data Vol. 10122; pp. 45 - 58
• Main Authors: Lucia, Angelo, DiMaggio, Peter A.
• Format: Book Chapter
• Language: English
• Published: Switzerland Springer International Publishing AG 2016; Springer International Publishing
• Series: Lecture Notes in Computer Science
• Subjects: Acetyl Phosphate; Flux Balance Analysis; Metabolic Network; Nash Equilibrium; Nash Equilibrium Problem

A novel approach to metabolic network analysis using a Nash Equilibrium formulation is proposed. Enzymes are considered to be players in a multi-player game in which each player attempts to minimize the dimensionless Gibbs free energy associated with the biochemical reaction(s) it catalyzes subject...