A Nash Equilibrium Approach to Metabolic Network Analysis

A novel approach to metabolic network analysis using a Nash Equilibrium formulation is proposed. Enzymes are considered to be players in a multi-player game in which each player attempts to minimize the dimensionless Gibbs free energy associated with the biochemical reaction(s) it catalyzes subject...

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Bibliographic Details
Published inMachine Learning, Optimization, and Big Data Vol. 10122; pp. 45 - 58
Main Authors Lucia, Angelo, DiMaggio, Peter A.
Format Book Chapter
LanguageEnglish
Published Switzerland Springer International Publishing AG 2016
Springer International Publishing
SeriesLecture Notes in Computer Science
Subjects
Acetyl Phosphate
Flux Balance Analysis
Metabolic Network
Nash Equilibrium
Nash Equilibrium Problem
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Summary:A novel approach to metabolic network analysis using a Nash Equilibrium formulation is proposed. Enzymes are considered to be players in a multi-player game in which each player attempts to minimize the dimensionless Gibbs free energy associated with the biochemical reaction(s) it catalyzes subject to elemental mass balances. Mathematical formulation of the metabolic network as a set of nonlinear programming (NLP) sub-problems and appropriate solution methodologies are described. A small example representing part of the production cycle for acetyl-CoA is used to demonstrate the efficacy of the proposed Nash Equilibrium framework and show that it represents a paradigm shift in metabolic network analysis.
ISBN:3319514687
9783319514680
ISSN:0302-9743
1611-3349
DOI:10.1007/978-3-319-51469-7_4