Spectrum of Kidney Diseases in Patients With Hepatitis C Virus Infection: A 10-Year Study

Objectives: To study the pathologic spectrum of kidney diseases in patients with hepatitis C virus infection (HCV+). Methods: Native kidney biopsy specimens in HCV+ patients were reviewed. Results: A total of9,836 native kidney biopsy specimens were evaluated from January 2007 to December 2016, of w...

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Published inAmerican journal of clinical pathology Vol. 156; no. 3; pp. 399 - 408
Main Authors Guo, Shunhua, Kapp, Meghan E, Beltran, Diego M, Cardona, Cesar Y, Caster, Dawn J, Reichel, Ronald R, Fogo, Agnes B
Format Journal Article
LanguageEnglish
Published Chicago Oxford University Press 01.09.2021
Subjects
Antiviral agents
Biopsy
Blood diseases
Care and treatment
Editor's Choice
Glomerulonephritis
Health aspects
Hepatitis C
Hepatitis C virus
Infection
Infections
Kidney diseases
Medical research
Medicine, Experimental
Original
Virus diseases
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Summary:Objectives: To study the pathologic spectrum of kidney diseases in patients with hepatitis C virus infection (HCV+). Methods: Native kidney biopsy specimens in HCV+ patients were reviewed. Results: A total of9,836 native kidney biopsy specimens were evaluated from January 2007 to December 2016, of which 273 (2.8%) were from HCV+ patients, and of these, 115 (42.1%) had diagnoses consistent with HCV-associated glomerulonephritis (GN). Non-HCV-associated kidney diseases comprised most diagnoses (158 cases, 57.9%) including non-immune complex-mediated kidney diseases (127 cases, 46.5%) and other immune complex-mediated glomerular diseases (31 cases, 11.4%). Forty-one (40.6%) patients had HCV-associated GN among 101 HCV+ patients from 2007 to 2011 vs 74 (43.0%) patients with HCVassociated GN among 172 HCV+ patients from 2012 to 2016. HCV-associated GN showed five morphologic patterns: focal proliferative (5.2%), diffuse mesangial proliferative (50.4%), diffuse membranoproliferative (28.7%), proliferative GN with crescentic lesions (7.8%), and membranous patterns (7.8%). Conclusions: We found a spectrum of pathologic changes in renal biopsy specimens of HCV+ patients, with most having diseases unrelated to HCV infection, HCV-associated GN showing five morphologic patterns, and availability of effective HCV antiviral therapy not yet resulting in major changes in the spectrum of kidney diseases in these patients. Key Words: Hepatitis C virus (HCV); Kidney disease; HCV-associated glomerulonephritis; Cryoglobulinemia
ISSN:0002-9173
1943-7722
DOI:10.1093/AJCP/AQAA238